ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
Alcohol Dehydrogenase 1B (class I), beta polypeptide LO000002CADH1B44q21-q23
Synonyms: ADH2 ; alcohol dehydrogenase 1B (class I), beta polypeptide ; alcohol dehydrogenase 2 (class I), beta polypeptide ;
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM description    UniGene   PharmGKB Gene Information   Genopedia (HuGE Navigator)   
References: See References
Locus Description: The Class I Alcohol Dehydrogenase (ADH) gene ADH1B, previously known as ADH2. The cluster of the three Class I ADH genes is listed separately as "Alcohol Dehydrogenase, Class I Gene cluster" (UID=LO000235K).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
A/G SNP   06
6-site haplotype   064
E_rs1587264_10rs1587264   100217783Now associated with LOC10050705350
C___2688455_1_rs1042026   100228466109
C___8829465_20rs17033   100228945103
exon9 Arg370Cysrs2066702   10022901794
rs17028834rs17028834   10023260050
C__25939834_10rs28626993   10023519444
intron3 RsaI rs2066701   10023841391
E_rs2075633_10rs2075633   10023899876
C__25931998_10rs4147536   10023911276
Thr60Serrs6413413   10023928417
exon3 Arg48Hisrs1229984   100239319241
rs1353621rs1353621   10024157551
C_2688471rs1159918   10024300992
E_rs6810842_10rs6810842   10024344564
rs1229982rs1229982   10024393288
rs3811802rs3811802   10024422155
C__27519856_10rs3811801   10024431986
rs1693439rs1693439   10024548978
rs9307239rs9307239   10024693778
rs1789888rs1789888   10024757051
Asn57Lysrs1041969    1004583141

References:
- Edenberg HJ. "Regulation of the mammalian alcohol dehydrogenase genes". Prog. Nucleic Acid Res. Mol. Biol. 64:295-341. (2000) Online citation.

- Osier MV, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB, and Kidd KK. "Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism". Am. J. Hum. Genet. 64:1147-1157. (1999) Online citation.

- Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi A, Okonofua F, Parnas J, Schulz LO, Bertranpetit J, Bonne-Tamir B, Lu RB, Kidd JR, Kidd KK. "A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity". Am J Hum Genet 71:84-99. (2002) Online citation.

- Osier MV. "Genetic Variation and Linkage Disequilibrium in the Human Alcohol Dehydrogenase Genes". Dissertation, Yale University (2002)

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan