ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
D1S80LO000333JD1S8011p36-p35
Synonyms: MCT118 ;
Sites List: See Sites List
External Resources: GenBank sequence   CHLC markers   UniSTS Marker Information   
References: See References
Locus Description: The highly variable region on the short arm of the first chromosome (D1S8O) was characterized by Kasai and colleagues (1990) [PubMed ID: 2230693] as a restriction length polymorphism detectable by probe pMCT1 18. Sequencing of flanking regions of this 16-nucleotide repeat enabled design of primers by which amplification of fragments in the range of 370-800 base pairs (bp) was possible. The nomenclature of current alleles reflects the number of repeats in amplified fragments. This system is extensively studied in world populations and has proved to be a very useful marker for genetic diversity and forensic applications [PubMed ID: 10885195].
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
D1S80   239068442

References:
- Da Silva WA Jr, Bortolini MC, Meyer D, Salzano FM, Elion J, Krishnamoorthy R, Schneider MP, De Guerra DC, Layrisse Z, Castellano HM, Weimer TD, Zago MA. "Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci.". Am. J. Phys. Anthropol. 109:425-437. (1999) Online citation.

- Drmic I, Schanfield MS, Andjelinovic S, Galavotti R, Gojanovic MD, Trabetti E, Marasovic D, Primorac D, Pignatti PF. "Allele Frequency of Six Highly Polymorphic DNA loci in the Croatian Population". Hum. Biol. 70:949-957. (1998) Online citation.

- Kasai K, Nakamura Y, White R. "Amplification of a variable number of tandem repeats (VNTR) locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science". J. Forensic Sci. 35:1196-200. (1990) Online citation.

- Mastana SS, Reddy PH, Das MK, Reddy P, Das K. "Molecular Genetic Diversity in 5 Populations of Madhya Pradesh, India". Hum. Biol. 72:499-510. (2000) Online citation.

- Vallinoto AC, Cayres-Vallinoto IM, Zago MA, Santos SE, Guerreiro JF. "D1S80 Polymorphismin Amerindians from the Amazon Region of Brazil". Hum. Biol. 70:507-516. (1998) Online citation.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan