|Name||ALFRED UID||Locus Symbol||Chromosome||Band Position|
|Fibrinogen, A alpha polypeptide||LO000359R||FGA||4||4q28|
See Sites List FGA includes one of the 13 CODIS Core STR markers (SI000529Q).
External Resources: Entrez Gene Locus Information OMIM description GenBank sequence GenBank sequence GenBank sequence GenBank sequence GenBank sequence PharmGKB Gene Information Genopedia (HuGE Navigator)
References: See References
Locus Description: The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. FGA consists of six exons and 5 introns, with an untranslated region of approximately 1Kb on the 3' end (Fu et al., 1992). Fibrinogen is cleaved by thrombin to form fibrin, important in the clotting of blood and the products of which regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types including fibroblasts, endothelial and smooth muscle cells (Herrick et al., 1999).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
FGA includes one of the 13 CODIS Core STR markers (SI000529Q).
| Site Name |
(Navigates to ALFRED
|dbSNP rs# |
(Navigates to dbSNP
|FGA tetranucleotide STRP||   ||155728500||165|
- Herrick S, Blanc-Brude O, Gray A, Laurent G. "Fibrinogen". Int J Biochem Cell Biol. 31:741-746. (1999) Online citation.
- Lazaruk K, Wallin J, Holt C, Nguyen T, Walsh PS. "Sequence variation in humans and other primates at six short tandem repeat loci used in forensic identity testing". Forensic Sci Int. 119:1-10. (2001) Online citation.
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan