|Name||ALFRED UID||Locus Symbol||Chromosome||Band Position|
|ATP-binding cassette, sub-family C (CFTR/MRP), member 11||LO000792S||ABCC11||16||q12.1|
See Sites List
External Resources: Entrez Gene Locus Information OMIM Locus Description GenBank mRNA Sequence GenBank Complete Sequence UniGene GDB Gene Information PharmGKB Gene Information
References: See References
Locus Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. Yabuuchi et al. (2001) determined that the ABCC11 gene contains 30 exons spanning 68 kb and that the separation between the ABCC11 and ABCC12 genes is about 20 kb. A SNP in this gene is responsible for determination of human earwax type. Multiple alternatively spliced transcript variants have been described for this gene.
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
| Site Name |
(Navigates to ALFRED
|dbSNP rs# |
(Navigates to dbSNP
|Exon29 del27||   ||0||28|
|G/A SNP (Gly180Arg)||rs17822931   ||48258198||101|
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan