|Name||ALFRED UID||Locus Symbol||Chromosome||Band Position|
|Period homolog 3||LO000914O||PER3||1||p36.23|
See Sites List
External Resources: Entrez Gene Locus information OMIM Locus Description GDB Gene Information UniGene GenBank Genomic Sequence
References: See References
Locus Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. PER3 is a component of the mammalian circadian system , although its precise role is unknown. PER3 was cloned & sequenced. Homology and conserved motifs were determined (PMID: 14750904) . Disturbances in PER gene expression may result in disruption of the control of the normal circadian clock, thus benefiting the survival of cancer cells and promoting carcinogenesis ( Chen et.al ,PMID: 15790588 ). Polymorphism of period 3 (647 Val/Gly) is implicated in tendency of diurnal preference in seasonal depression as revealed by self-reported morningness-eveningness scores, with higher scores found in individuals with at least one glycine allele ( PMID: 12655319).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
| Site Name |
(Navigates to ALFRED
|dbSNP rs# |
(Navigates to dbSNP
|Biallelic VNTR||   ||0||23|
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan