ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
Period homolog 3LO000914OPER31p36.23
Synonyms: GIG13 ; clock ; circadian genes ;
Sites List: See Sites List
External Resources: Entrez Gene Locus information   OMIM Locus Description   GDB Gene Information    UniGene   GenBank Genomic Sequence   
References: See References
Locus Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. PER3 is a component of the mammalian circadian system , although its precise role is unknown. PER3 was cloned & sequenced. Homology and conserved motifs were determined (PMID: 14750904) . Disturbances in PER gene expression may result in disruption of the control of the normal circadian clock, thus benefiting the survival of cancer cells and promoting carcinogenesis ( Chen et.al ,PMID: 15790588 ). Polymorphism of period 3 (647 Val/Gly) is implicated in tendency of diurnal preference in seasonal depression as revealed by self-reported morningness-eveningness scores, with higher scores found in individuals with at least one glycine allele ( PMID: 12655319).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
Biallelic VNTR   023
rs228729rs228729   784569570
rs697686rs697686   785021870
rs875994rs875994   785291951
rs228682rs228682   785634670
rs707467rs707467   786168450
rs228642rs228642   786329351
rs228644rs228644   786608350
rs10864316rs10864316   787207651
rs10462018rs10462018   787962770
rs10462020rs10462020   788068370
rs10127838rs10127838   788178070
rs10462021rs10462021   789713351
rs228654rs228654   789722851

References:
- Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG "Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers". Carcinogenesis. 26:1241-6. (2005) Online citation.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan