ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
Taste receptor, type 2, member 16LO003182OTAS2R167q31
Synonyms: T2R16 ;
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM Locus Description   GDB Gene Information    UniGene   GenBank Sequence   
References: See References
Locus Description: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. The TAS2R genes, with a size range of 876 -1,014 bp, have intronless coding regions and code for G protein coupled receptors. TAS2R16, is present in taste receptor cells on the tongue and is activated by bitter beta-glucopyranosides. A number of coding SNPs (cSNPs) have been identified in human bitter-taste receptor genes. This gene is located on 7q in a region reported to exhibit linkage with alcohol dependence. Hinrichs et al. (2006) found that a cSNP,K172N, in the TAS2R16 gene shows significant association with alcohol dependence.
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
TAS2R16 gene LI SNPs 3-site haplotypers1204018   1226247700
rs846672rs846672   12263018087
rs17614266rs17614266   12263255954
4-site haplotype   12263326444
rs1357949rs1357949   12263326454
Thr282Thrrs1204014   12263484393
Phe240Valrs28371581   12263497156
Val235Metrs28371580   12263498656
Arg222Hisrs860170   12263502493
Ala221Valrs28371579   12263502756
Asn216Asprs28371578   12263504356
Gln177Prors28371577   12263515956
Lys172Asnrs846664   12263517395
Pro161Serrs28371576   12263520856
Leu154Leurs2233989   12263522956
Leu116Prors28371575   12263534256
Ile114Valrs28371574   12263534956
Thr111Thrrs28371573   12263535656
Val101Valrs2692396   12263538691
Val101Metrs28371571   12263538856
Thr100Thrrs2233988   12263538956
rs702424rs702424   12263641344
rs9691345rs9691345   12263797687
rs1525464rs1525464   12264068954

References:
- Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM. "Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence". Am J Hum Genet. 78:103-11. (2006) Online citation.

- Soranzo N, Bufe B, Sabeti PC, Wilson JF, Weale ME, Marguerie R, Meyerhof W, Goldstein DB. "Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16". Curr Biol. 15:1257-1265. (2005) Online citation.

- Strausberg RL etal. "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99:16899-903. (2002) Online citation.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan