ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)LO010929VCXCL1210q11.1
Synonyms: PBSF ; SDF1 ; SDF1A ; SDF1B ; TPAR1 ; SCYB12 ; SDF-1a ; SDF-1b ; TLSF-a ; TLSF-b ;
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM Locus Description    UniGene   GenBank Sequence   
References: See References
Locus Description: CXCL12 is a CXC-type chemokine that plays important roles in hematopoiesis, development, and organization of the immune system and supports the survival or growth of a variety of normal or malignant cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli. Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that binds to its sole counterreceptor, CXCR4. This interaction has a pivotal role in the directional migration of cancer cells during the metastatic process.
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
rs10900029rs10900029   4418222650
rs1065297rs1065297   4418598250
G801Ars1801157   44188263146
rs2297630rs2297630   4419155451
rs4948878rs4948878   4419482751
rs2839692rs2839692   4419487351
rs2839690rs2839690   4419517250
rs11592974rs11592974   4419750750
rs3780891rs3780891   4419871951
rs2861442rs2861442   4420496551
rs266094rs266094   4486430051
rs197452rs197452   4487024051
rs266087rs266087   4487106251
rs266086rs266086   4487183350

References:
- Winkler C, Modi W, Smith MW, Nelson GW, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert JJ, O'Brien TR, Jacobson LP, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, O'Brien SJ. "Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC)". Science 279:389-93. (1998) Online citation.

Top

© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan