ALFRED: allele frequency database

The ALlele FREquency Database
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.

ALFRED detailed record information

Population Information

Name	ALFRED UID	Primary Language	Language Family
English	PO000134I	ENGLISH	Indo-European

Synonyms:
Geographic Location¹: 59N, 10W; 50N, 2E

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: Ethnologue: Language Description Record Ethnologue: Language Map Record
References: See references
Population Description: England is the main political division of the United Kingdom. The majority of the English people are descendants from Celtic and Iberian people, and due to later invasions Romans, Anglo-Saxons, Danes, and Normans. Approximately 60% of the population follows the state church, the Church of England, a protestant Episcopal denomination. The Roman Catholic Church has the second leading followers. The English language has spread throughout the world and is spoken by 508 billion people throughout the world (The Ethnologue, 1999). As of 2001 the population for the whole of the United Kingdom was almost 60 billion (World Fact Book, 2001).
References:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: North-west Derbyshire

Sample UID: SA000959X

Sample Description:This sample consists of individuals from the north-west region of Derbyshire. Derbyshire is a county in the East Midlands region of England, UK. Birthplaces of donors and their grandparents were noted and formed the basis for geographical classification of this sample. Only donors with at least three generations of residence in the county and the region were included in this research. Appropriate consent was obtained.

Number of Chromosomes: 196

Relation to Other Samples:

References:
- Mastana S, Lee D, Singh PP, Singh M. "Molecular genetic variation in the East Midlands, England: analysis of VNTR, STR and Alu insertion/deletion polymorphisms". Ann Hum Biol. 30:538-550. (2003) Online citation.

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: South Derbyshire

Sample UID: SA003235N

Sample Description:This sample consists of individuals from South Derbyshire .

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 332

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Mastana SS, Calderon R, Pena J, Reddy PH, Papiha SS. "Anthropology of the apoplipoprotein E (apo E) gene: low frequency of apo E4 allele in Basques and in tribal (Baiga) populations of India". Ann Hum Biol. 25:137-43. (1998) Online citation.

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: NW Derbyshire

Sample UID: SA003237P

Sample Description:This sample consists of individuals from NW Derbyshire .

Number of Chromosomes: 178

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Manchester

Sample UID: SA002750O

Sample Description:This sample consists of individuals from Manchester, England who were part of multicenter case-conrol study conducted from 2002-2005 in 12 centres from 8 European countries. This study is called ARCAGE (Alcohol-related Cancers and genetic susceptibility in Europe). All participants were interviewed with a structured questionnaire.

Number of Chromosomes: 312

Relation to Other Samples:

References:
- Hashibe M, McKay JD, Curado MP, Oliveira JC, Koifman S, Koifman R, Zaridze D, Shangina O, W�nsch-Filho V, Eluf-Neto J, Levi JE, Matos E, Lagiou P, Lagiou A, Benhamou S et.al. "Multiple ADH genes are associated with upper aerodigestive cancers". Nat Genet. 40:707-9. (2008) Online citation.

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Leicestershire

Sample UID: SA000962R

Sample Description:This sample consists of individuals from Leicestershire. Leicestershire is a county in the East Midlands region of England, UK. Birthplaces of donors and their grandparents were noted and formed the basis for geographical classification of this sample. Only donors with at least three generations of residence in the county and the region were included in this research. Appropriate consent was obtained.

Number of Chromosomes: 208

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Nottinghamshire

Sample UID: SA000963S

Sample Description:This sample consists of individuals from Nottinghamshire. Nottinghamshire is a county in the East Midlands region of England, UK. Birthplaces of donors and their grandparents were noted and formed the basis for geographical classification of this sample. Only donors with at least three generations of residence in the county and the region were included in this research. Appropriate consent was obtained.

Number of Chromosomes: 196

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: NE Derbyshire

Sample UID: SA003236O

Sample Description:This sample consists of individuals from NE Derbyshire.

Number of Chromosomes: 170

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Wessex region

Sample UID: SA003159S

Sample Description:This sample consists of female volunteers who were either staff at the Princess Anne Hospital, Southampton, UK. The sample is from a geographical area which has predominantly an Anglo-Saxon population.

Number of Chromosomes: 466

Relation to Other Samples:

References:
- Campbell IG, Baxter SW, Eccles DM, Choong DY. "Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer". Breast Cancer Res. 4:(2002) Online citation.

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Newcastle

Sample UID: SA002751P

Sample Description:This sample consists of individuals from Newcastle, England who were part of multicenter case-conrol study conducted from 2002-2005 in 12 centres from 8 European countries. This study is called ARCAGE (Alcohol-related Cancers and genetic susceptibility in Europe). All participants were interviewed with a structured questionnaire.

Number of Chromosomes: 190

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: North-east Derbyshire

Sample UID: SA000960P

Sample Description:This sample consists of individuals from the north-east region of Derbyshire. Derbyshire is a county in the East Midlands region of England, UK. Birthplaces of donors and their grandparents were noted and formed the basis for geographical classification of this sample. Only donors with at least three generations of residence in the county and the region were included in this research. Appropriate consent was obtained.

Number of Chromosomes: 204

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Leicestershire

Sample UID: SA003234M

Sample Description:This sample consists of English from Leicestershire, UK.

Number of Chromosomes: 204

Relation to Other Samples:

Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: South Derbyshire

Sample UID: SA000961Q

Sample Description:This sample consists of individuals from the south region of Derbyshire. Derbyshire is a county in the East Midlands region of England, UK. Birthplaces of donors and their grandparents were noted and formed the basis for geographical classification of this sample. Only donors with at least three generations of residence in the county and the region were included in this research. Appropriate consent was obtained.

Number of Chromosomes: 200

Relation to Other Samples:

¹Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan