ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Polymorphism Information

NameALFRED UIDLocus NameLocus Symbol
intron 1 TaqI B SI000148NDopamine Receptor D2DRD2
FstAvg Het# Populations Typed
0.1790.338102
Synonyms: rs1079597 ;
Frequency on Map:    
Frequency Display Formats:     
Estimated Heterozygosity: 
Frequency Download:   
External Resources:  Typing Protocol Record  GenBank sequence Record  GenBank sequence Record  dbSNP rs# Record  PharmGKB Variant Information Record  
References: See References
Polymorphism Description:  A A/G SNP in intron 1 that alters a TaqI site located 882 bp upstream of exon 2 and 12 bp upstream of the polymorphic BclI site.
Ancestral Allele:  Site Present
Ancestral Allele Determine by: Sequence on primate DNA
Alleles:
Allele NameAllele SymbolDescription
TaqI Site AbsentA5'-tcagaatcacctat TC A A aaggcgaatccgatc-3'
TaqI Site presentG5'-tcagaatcacctat TC G A aaggcgaatccgatc-3'

References:
- Castiglione CM, Deinard AS, Speed WC, Sirugo G, Rosenbaum HC, Zhang Y, Grandy DK, Grigorenko EL, Bonne-Tamir B, Pakstis AJ, Kidd JR, Kidd KK. "Evolution of haplotypes at the DRD2 locus". Am. J. Hum. Genet. 57:1445-56. (1995) Online citation.

- Chakrabarti CS, Roy M, Sengupta NK, Lalthantluanga R, Majumder PP. "Genetic relationships among some tribal groups inhabiting the north-eastern, eastern and sub-Himalayan regions of India". Ann Hum Genet 66:361-368. (2002) Online citation.

- Iyengar S, Seaman M, Deinard AS, Rosenbaum HC, Sirugo G, Castiglione CM, Kidd JR, Kidd KK. "Analyses of cross-species polymerase chain reaction products to infer the ancestral state of human polymorphisms". DNA Seq. 8:317-27. (1998) Online citation.

- Kidd KK, Pakstis AJ, Castiglione CM, Kidd JR, Speed WC, Goldman D, Knowler WC, Lu RB, Bonne-Tamir B. "DRD2 haplotypes containing the TaqI A1 allele: implications for alcoholism research". Alcohol. Clin. Exp. Res. 20:697-705. (1996) Online citation.

- Sawyer SL, Mukherjee N, Pakstis AJ, Feuk L, Kidd JR, Brookes AJ, Kidd KK. "Linkage disequilibrium patterns vary substantially among populations". Eur J Hum Genet 13:677-686. (2005) Online citation.

- Suarez BK, Parsian A, Hampe CL, Todd RD, Reich T, Cloninger CR. "Linkage disequilibria at the D2 dopamine receptor locus (DRD2) in alcoholics and controls". Genomics 19:12-20. (1994) Online citation.

© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan