ALFRED detailed record information
|Fst||Avg Het||# Populations Typed|
Frequency Display Formats:
External Resources: GenBank sequence Record Typing Protocol Record
References: See References
Polymorphism Description: This is a 40 bp VNTR(Variable Number Tandem Repeat) in 3' untranslated region of the gene SLC6A3, just upstream of the polyadenylation site. Since this VNTR is not in the coding region there are no structural alterations to the DAT1 protein. This polymorphism has shown to be associated with various neuro psychiatric disorders.
Note:The fragment size in bps in the allele descriptions are according to Vandenbergh et al.,1992.
|Allele Name||Allele Symbol||Description|
|10||10||10 repeats of 40 bp unit (480bp)|
|11||11||11 repeats of 40 bp unit (520bp)|
|12||12||12 repeats of 40 bp unit (560bp)|
|13||13||13 repeats of 40 bp unit (600bp)|
|3||3||3 repeats of 40 bp unit (200bp)|
|6||6||6 repeats of 40 bp unit (320bp)|
|7||7||7 repeats of 40 bp unit (360bp)|
|8||8||8 repeats of 40 bp unit (400bp)|
|9||9||9 repeats of 40 bp unit (440bp)|
- Kang AM, Palmatier MA, Kidd KK. "Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3)". Biological Psychiatry 46:151-60. (1999) Online citation.
- Vandenbergh DJ, Persico AM, Uhl GR.
"A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs". Brain Res. Mol. Brain Res. 15:161-6. (1992) Online citation.
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan