|Name||ALFRED UID||Locus Name||Locus Symbol|
|GYPA||SI001090K||Glycophorin A (includes MN blood group)||GYPA|
|Fst||Avg Het||# Populations Typed|
References: See References
Polymorphism Description: One of the PolyMarker(PM) loci used in forensics for DNA typing using the Amplitype PM PCR Amplification and Typing Kit.
The two alleles of the classical MN blood groups are M and N which correspond to alleles A and B from the kit.The molecular difference of the two alleles lie at codons 1 and 5 of the Glycophorin A cDNA sequence.
Allele Name AlleleName AminoAcid at codon position (ClassicalMN) (From the kit) 1 5 M A Serine(TCA) Glycine(GGT) N B Leucine(TTA) GltamicAcid(GAG)
|Allele Name||Allele Symbol||Description|
- Peterson BL, Su B, Chakraborty R, Budowle B, Gaensslen RE. "World population data for the HLA-DQA1, PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines". J Forensic Sci. 45:118-46. (2000) Online citation.
- Siebert PD, Fukuda M. "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. ". Proc Natl Acad Sci U S A. 84:6735-9. . (1987) Online citation.
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan