ALFRED: allele frequency database

The ALlele FREquency Database
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.

ALFRED detailed record information

Polymorphism Information

Name	ALFRED UID	Locus Name	Locus Symbol
GYPA	SI001090K	Glycophorin A (includes MN blood group)	GYPA

Fst	Avg Het	# Populations Typed
0.049	0.439	23

Synonyms:
Frequency Display Formats:

Estimated Heterozygosity:

Frequency Download:

External Resources:
References: See References
Polymorphism Description: One of the PolyMarker(PM) loci used in forensics for DNA typing using the Amplitype PM PCR Amplification and Typing Kit.

The two alleles of the classical MN blood groups are M and N which correspond to alleles A and B from the kit.The molecular difference of the two alleles lie at codons 1 and 5 of the Glycophorin A cDNA sequence.


Allele Name         AlleleName      AminoAcid at codon position    
(ClassicalMN)      (From the kit)      1                5 
   M                   A             Serine(TCA)      Glycine(GGT)
   N                   B             Leucine(TTA)     GltamicAcid(GAG)

Alleles:

Allele Name	Allele Symbol	Description
A	A
B	B

References:
- Budowle B, Lindsey JA, DeCou JA, Koons BW, Giusti AM, Comey CT. "Validation and population studies of the loci LDLR, GYPA, HBGG, D7S8, and Gc (PM loci), and HLA-DQ alpha using a multiplex amplification and typing procedure". J Forensic Sci. 40:45-54.. (1995) Online citation.

- Peterson BL, Su B, Chakraborty R, Budowle B, Gaensslen RE. "World population data for the HLA-DQA1, PM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines". J Forensic Sci. 45:118-46. (2000) Online citation.

- Siebert PD, Fukuda M. "Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. ". Proc Natl Acad Sci U S A. 84:6735-9. . (1987) Online citation.

© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan