ALFRED: allele frequency database

The ALlele FREquency Database
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.

ALFRED detailed record information

Polymorphism Information

Name	ALFRED UID	Locus Name	Locus Symbol
FUT2 fusion gene	SI001244L	Fucosyltransferase 2 (secretor status included)	FUT2

Fst	Avg Het	# Populations Typed
0.049	0.007	18

Synonyms:
Frequency Display Formats:

Estimated Heterozygosity:

Frequency Download:

External Resources:
References: See References
Polymorphism Description: A polymorphism resulting in a fusion of 3' region of FUT2 with 5' region of nearby pseudogene, without the C357T neutral mutation. The crossover region has been shown to be within a 61 bp stretch corresponding to regions between bases 253 and 313 of the pseudogene and between bases 211 and 271 of FUT2. The mutation leads to a loss of five EcoRI sites along the 38.7 kb span of FUT2 and the pseudogene.
Alleles:

Allele Name	Allele Symbol	Description
Wt	Wt	Wild type non-fused gene
fus	fus	Fusion form of FUT2/pseudogene

References:
- Koda Y, Soejima M, Liu Y, Kimura H. "Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency". Am J Hum Genet. 59:343-350. (1996) Online citation.

© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan