ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Population Information

NameALFRED UIDPrimary LanguageLanguage Family
MexicanPO000504J

Synonyms:
Geographic Location1:  32.75N, 117.5W; 14.5N, 86W  

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: 
References: See references
Population Description: Being curated
References:


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Central Mexico

Sample UID: SA001788Y

Sample Description:This sample consists of unrelated individuals from teh central region of Mexico (states of Mexico, Morelos, Queretaro, Puebla and Distrito Federal).

Number of Chromosomes: 422

Relation to Other Samples:

References:
- Hernandez-Gutierrez S, Hernandez-Franco P, Martinez-Tripp S, Ramos-Kuri M, Rangel-Villalobos H. "STR data for 15 loci in a population sample from the central region of Mexico". Forensic Sci Int. 151:97-100. (2005) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Valley of Mexico

Sample UID: SA001591Q

Sample Description:This sample consists of unrelated individuals from the Valley of Mexico, including Mexico City (Mexico D.F.) and satellite cities.

Number of Chromosomes: 484

Relation to Other Samples:

References:
- Luna-Vazquez A, Vilchis-Dorantes G, Aguilar-Ruiz MO, Bautista-Rivas A, Rojo-Nava AL, Rios-Barrios E, Rangel-Villalobos H. "Population data for 15 loci (Identifiler Kit) in a sample from the Valley of Mexico". Leg Med (Tokyo). 7:331-333. (2005) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizo

Sample UID: SA002114I

Sample Description:This sample consists of unrelated male and female Mestizos from Mexico.

Number of Chromosomes: 114

Relation to Other Samples:

References:
- Goedde HW, Agarwal DP, Fritze G, Meier-Tackmann D, Singh S, Beckmann G, Bhatia K, Chen LZ, Fang B, Lisker R "Distribution of ADH2 and ALDH2 genotypes in different populations". Hum Genet. 88:344-6. (1992) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexico

Sample UID: SA002708R

Sample Description:This sample consists of specimens randomly selected from blood spots from newborns in hospitals in Mexico. Samples were obtained from the remainder of the blood spot specimens collected for hypothyroidism screening. Selection was stratified to include equal numbers of males and females in the final sample. This study was conducted under the auspices of the International Clearinghouse for Birth Defect Monitoring Systems (ICBDMS) and was coordinated through its head office, the International Center on Birth Defects. Local review boards approved the study.In all cases personal identifiers were removed before data were provided to ICBD for epidemiological analysis.

Number of Chromosomes: 1000

Relation to Other Samples:

References:
- Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, Renlund M, Stoll C, Alembik Y, Dott B, Czeizel AE, Gelman-Kohan Z, Scarano G, Bianca S, Ettore G, Tenconi R, Bellato S, Scala I, Mutchinick OM, López MA, de Walle H, Hofstra R, Joutchenko L, Kavteladze L, Bermejo E, Martínez-Frías ML, Gallagher M, Erickson JD, Vollset SE, Mastroiacovo P, Andria G, Botto LD. "Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide". J Med Genet. 40:619-25.. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexicans

Sample UID: SA003017L

Sample Description:This sample consists of Mexicans . This is a mixed sample from Western Mexico comprising urban, rural and Indian Population. Written informed consent was obtained from each participant. THe study was approved by the Human Ethics Committee of each institute.

Number of Chromosomes: 630

Relation to Other Samples:

References:
- Ueki M, Takeshita H, Fujihara J, Iida R, Yuasa I, Kato H, Panduro A, Nakajima T, Kominato Y, Yasuda T. "Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme". Clin Chim Acta. 407:20-4. (2009) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican

Sample UID: SA003589Z

Sample Description:This sample consists of Mexican Mestizo from Mexico city. The study protocol was reviewed and approved by the Human Ethical Committee, and Medical Research Council of the Instituto Mexicano Del Seguro Social. Informed written consent was obtained from all subjects before enrollment.

Number of Chromosomes: 360

Relation to Other Samples:

References:
- Isordia-Salas I, Leaños-Miranda A, Borrayo-Sánchez G. "The Glu298ASP polymorphism of the endothelial nitric oxide synthase gene is associated with premature ST elevation myocardial infarction in Mexican population". Clin Chim Acta 411:553-7. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizo

Sample UID: SA003127N

Sample Description:This sample consists of unrelated Mexican Mestizos. The sample included university students or employees and informed consent was obtained from all participants.

Number of Chromosomes: 202

Relation to Other Samples:

References:
- Dávalos IP, Olivares N, Castillo MT, Cantú JM, Ibarra B, Sandoval L, Morán MC, Gallegos MP, Chakraborty R, Rivas F "The C677T polymorphism of the methylenetetrahydrofolate reductase gene in Mexican mestizo neural-tube defect parents, control mestizo and native populations". Ann Genet. 43:89-92. (2000) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizo

Sample UID: SA003541N

Sample Description:This sample consists of Mestizo. Written informed consent was obtained from each participant. The study was approved by the Human Ethics Committees of the participating institutes.

Number of Chromosomes: 120

Relation to Other Samples:

References:
- Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K, Kato H, Panduro A, Tongu M, Takeshita H. "Functional and Genetic Survey of All Known Single-Nucleotide Polymorphisms Within the Human Deoxyribonuclease I Gene in Wide-Ranging Ethnic Groups". DNA Cell Biol. (Epub, ahead of print) (2011) Online citation.

- Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A. "A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity". Int J Biochem Cell Biol. 42:1216-25. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexicans - Mexico City

Sample UID: SA003368U

Sample Description:This sample consists of Mexican individuals.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 556

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Gamboa R, Vargas-Alarcón G, Medina-Urrutia A, Cardoso-Saldaña G, Hernández-Pacheco G, Zamora-González J, Posadas-Romero C. "Influence of the apolipoprotein E polymorphism on plasma lipoproteins in a Mexican population". Hum Biol. 73:835-43. (2001) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizos

Sample UID: SA003705P

Sample Description:This sample consists of Mestizos (an admixed population group with the descendants of Spanish Caucasian and Native Amerindians) from Quito area, Ecuador.

Number of Chromosomes: 84

Relation to Other Samples:

References:
- Poulsen L, Børsting C, Tomas C, González-Andrade F, Lopez-Pulles R, González-Solórzano J, Morling N. "Typing of Amerindian Kichwas and Mestizos from Ecuador with the SNPforID multiplex". Forensic Sci Int Genet. (Epub,ahead of print) (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexico

Sample UID: SA001254M

Sample Description:This sample consists of cosmopolitan Mestizo from the state of Neuvo Leon, Mexico. Samples were provided by Ricardo Cerda-Flores of IMSS, Neuvo Leon, and typed at the FBI Laboratory.

Number of Chromosomes: 286

Relation to Other Samples:

References:
- Budowle B, Shea B, Niezgoda S, Chakraborty R. "CODIS STR loci data from 41 sample populations". J Forensic Sci. 46:453-489. (2001) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican

Sample UID: SA001977Y

Sample Description:This sample consists of healthy, unrelated Mexicans who attended the Center for Research and Advanced Studies from the National Polytechnic Institute located in Mexico City, Mexico. Great care was taken in selecting individuals whose parents were Mexicans.

Number of Chromosomes: 428

Relation to Other Samples:

References:
- Rojas-Garcia AE, Solis-Heredia MJ, Pina-Guzman B, Vega L, Lopez-Carrillo L, Quintanilla-Vega B "Genetic polymorphisms and activity of PON1 in a Mexican population". Toxicol Appl Pharmacol. 205:282-9. (2005) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Western Mexicans

Sample UID: SA003861S

Sample Description:This sample consists of healthy control individuals of Mexican origin from Guadalajara, Mexico.

Number of Chromosomes: 132

Relation to Other Samples:

References:
- García-Bañuelos J, Panduro A, Gordillo-Bastidas D, Gordillo-Bastidas E, Muñoz-Valle JF, Gurrola-Díaz CM, Sánchez-Enríquez S, Ruiz-Madrigal B, Bastidas-Ramírez BE. "Genetic Polymorphisms of Genes Coding to Alcohol-Metabolizing Enzymes in Western Mexicans: Association of CYP2E1*c2/CYP2E1*5B Allele with Cirrhosis and Liver Function". Alcohol Clin Exp Res. (Epub, ahead of print) (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizo

Sample UID: SA003572R

Sample Description:This sample consists of healthy Mexican Mestizo individuals.

Number of Chromosomes: 252

Relation to Other Samples:

References:
- Rosas-Vargas H, Flores-Segura A, Guizada-Claure B, Vargas-Alarcón G, Granados J, Salamanca F, Coral-Vázquez R. "Endothelial nitric oxide synthase gene polymorphism in the Indian and Mestizo populations of Mexico". Hum Biol. 75:91-6. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican Mestizos

Sample UID: SA003462P

Sample Description:This sample consists of Mexican Mestizos. The individuals were healthy representing the general population reporting a Mexican family history of at least 3 generations. The sample was constituted by health workers and students of western Mexican origin from the Civil Hospital of Tepic, an urban population lacated approximately 210km apart from the Huichols community.

Number of Chromosomes: 436

Relation to Other Samples:

References:
- Gordillo-Bastidas E, Panduro A, Gordillo-Bastidas D, Zepeda-Carrillo EA, García-Bañuelos JJ, Muñoz-Valle JF, Bastidas-Ramírez BE. "Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele". Alcohol Clin Exp Res. 34:142-9. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mestizo

Sample UID: SA004187U

Sample Description:This sample consists of randomly selected unrelated healthy Mestizo subjects who are mixture of black and Hispanic populations.

Number of Chromosomes: 76

Relation to Other Samples:

References:
- Fujihara J, Yasuda T, Kato H, Yuasa I, Panduro A, Kunito T, Takeshita H. "Genetic variants associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase show wide variation across multiple populations". Arch Toxicol. 85:119-25. (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican, Chihuahua

Sample UID: SA001263M

Sample Description:This sample consists of unrelated individuals living in the State of Chihuahua in north-central Mexico.

Number of Chromosomes: 322

Relation to Other Samples:

References:
- Martinez-Gonzalez LJ, Martinez-Espin E, Fernandez-Rosado F, Moguel MA, Entrala C, Alvarez JC, Lorente JA, Budowle B. "Mexican population data on fifteen STR loci (Identifiler® Kit) in a Chihuahua (North Central Mexico) sample". J Forensic Sci. 50:236-238. (2005)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican Mestizo

Sample UID: SA002378U

Sample Description:This sample consists of healthy Mexican Mestizo individuals.

Number of Chromosomes: 140

Relation to Other Samples:

References:
- Zúñiga JA, Villarreal-Garza C, Flores E, Barquera R, Pérez-Hernández N, Montes de Oca JV, Cardiel MH, Vargas-Alarcón G, Granados J "Biological relevance of the polymorphism in the CCR5 gene in refractory and non-refractory rheumatoid arthritis in Mexicans". Clin Exp Rheumatol. 21:351-4. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican Mestizo

Sample UID: SA001850O

Sample Description:This sample consists of unrelated, healthy Mezican Mestizos from Northeastern Mexico.

Number of Chromosomes: 286

Relation to Other Samples:

References:
- Cerda-Flores RM, Budowle B, Jin L, Barton SA, Deka R, Chakraborty R. "Maximum likelihood estimates of admixture in Northeastern Mexico using 13 short tandem repeat loci". Am J Hum Biol. 14:429-439. (2002) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican

Sample UID: SA001101D

Sample Description:This sample consists of healthy unrelated individuals from the State of Jalisco, Mexico.

Number of Chromosomes: 346

Relation to Other Samples:

References:
- Rangel-Villalobos H, Rivas F, Torres-Rodriguez M, Jaloma-Cruz AR, Gallegos-Arreola MP, Lopez-Satow J, Cantu JM, Figuera LE. "Allele frequency distributions of six Amp-FLPS (D1S80, APO-B, VWA, TH01, CSF1PO and HPRTB) in a Mexican population". Forensic Sci Int. 105:125-129. (1999) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican

Sample UID: SA002496V

Sample Description:This sample consists of Mexicans.

Number of Chromosomes: 84

Relation to Other Samples:

References:
- Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW et.al. "Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes". Am J Hum Genet. 62:1507-15. (1998) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexico city

Sample UID: SA003119O

Sample Description:This sample consists of volunteers who were blood donors at the National Institute of Medical Sciences and Nutrition in Mexico city.

Number of Chromosomes: 600

Relation to Other Samples:

References:
- Guéant-Rodriguez RM, Guéant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sánchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM "Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations". Am J Clin Nutr. 83:701-7. (2006) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican_MXL

Sample UID: SA004110G

Sample Description:This sample is part of the 1000 genomes collection. The blood samples were collected in Los Angeles, California. All of the samples are from parent-adult child trios. All parents in the trios identified themselves as having at least three out of four grandparents who were born in Mexico

Number of Chromosomes: 132

Relation to Other Samples:

References:
- Corriel 1000 genomes collections sample descriptions Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Mexican Mestizos

Sample UID: SA003648V

Sample Description:This sample consists of Mexican mestizos who were the control group of non-diabetic individuals.

Number of Chromosomes: 416

Relation to Other Samples:

References:
- Villalobos-Comparán M et al. "The FTO gene is associated with adulthood obesity in the Mexican population". Obesity (Silver Spring) 16:2296-30. (2008) Online citation.


1Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan