ALFRED
      The ALlele FREquency Database   
A resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
MCM6 minichromosome maintenance deficient 6LO000912MMCM62q21
Synonyms: Mis5 ; P105MCM ; MCG40308 ;
Frequency Display Formats: 
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM Locus Description   GenBank mRNA Sequence    UniGene   GDB Gene Information   
References: See References
Locus Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (preRC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
Sites within this locus ordered by their chromosomal position in the latest NCBI build:
Site NamedbSNP rs#Chr-PositionStatus
D2S3015 STRP   0
rs4988262rs4988262   136320680
(-13907)C/Grs41525747   136325113
intron 13 C/T (-13910 ) SNPrs4988235   136325116
(-13913)C/Trs41456145   136325119
(-13915)G/Trs41380347   136325121
rs4988232rs4988232   136326141
rs4988203rs4988203   136332793
intron 9 G/A ( -22018 ) SNPrs182549   136333224
rs4988199rs4988199   136334990
rs4988186rs4988186   136338328
C__15793430_10rs3087343   136339013
rs4988177rs4988177   136339432
C___2140133_10rs3087353   136340187
E_rs1435577_10rs1435577   136341417
C__27478863_10rs3769001   136342548
E__rs191079_10rs191079   136350241
C__12044582_1_rs1057031   136350432

References:
- Lee JK, Hurwitz J. "Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures". Proc Natl Acad Sci U S A. 98:54-9. (2001) Online citation.

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© 2009 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan