ALFRED
      The ALlele FREquency Database   
A resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
MCM6 minichromosome maintenance deficient 6LO000912MMCM62q21
Synonyms: Mis5 ; P105MCM ; MCG40308 ;
Frequency Display Formats: 
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM Locus Description   GenBank mRNA Sequence    UniGene   GDB Gene Information   
References: See References
Locus Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (preRC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.
Sites within this locus ordered by their chromosomal position in the latest NCBI build:
Site NamedbSNP rs#Chr-PositionStatus# Populations
typed
D2S3015 STRP   05
rs4988262rs4988262   1363206801
(-13907)C/Grs41525747   1363251136
intron 13 C/T (-13910 ) SNPrs4988235   13632511617
(-13913)C/Trs41456145   1363251194
(-13915)G/Trs41380347   1363251219
rs4988232rs4988232   1363261411
rs4988203rs4988203   1363327931
intron 9 G/A ( -22018 ) SNPrs182549   13633322453
rs4988199rs4988199   1363349901
rs4988186rs4988186   1363383281
C__15793430_10rs3087343   13633901341
rs4988177rs4988177   1363394321
C___2140133_10rs3087353   13634018741
E_rs1435577_10rs1435577   13634141741
C__27478863_10rs3769001   13634254841
E__rs191079_10rs191079   13635024141
C__12044582_1_rs1057031   13635043241

References:
- Lee JK, Hurwitz J. "Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures". Proc Natl Acad Sci U S A. 98:54-9. (2001) Online citation.

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© 2010 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan