ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.
ALFRED detailed record information

Locus Information

NameALFRED UIDLocus SymbolChromosomeBand Position
Alcohol Dehydrogenase 1C (class I), gamma polypeptide LO000228MADH1C44q21-q23
Synonyms: ADH3 ; alcohol dehydrogenase 3 (class I), gamma polypeptide ;
Sites List: See Sites List
External Resources: Entrez Gene Locus Information   OMIM description   RefSeq mRNA    UniGene   PharmGKB Gene Information   Genopedia (HuGE Navigator)   
References: See References
Locus Description: The Class I Alcohol Dehydrogenase (ADH) gene ADH1C, previously known as ADH3. The cluster of the three Class I ADH genes is listed separately as "Alcohol Dehydrogenase, Class I Gene cluster" (UID=LO000235K).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description)		dbSNP rs#
(Navigates to dbSNP
reference page)		Chr-PositionStatus# Populations
typed
E_rs6810842_10rs6810842   100243445Now associated with ADH1B64
C__27519856_10rs3811801   100244319Now associated with ADH1B86
C___8829540_10rs1789891   100250419Now associated with rs178989182
C___2688487_10rs1789896   10025698440
rs1614972rs1614972   10025815588
exon 8 Pro352Thrrs35719513   10026078338
exon 8 Ile350Valrs698   100260789134
exon 6 Arg272Glnrs1693482   10026396594
intron 5 XbaI rs1625439   1002653255
Pro166Serrs34195308   1002660901
exon 5 HaeIIIrs1693425   10026611274
C___2688508_10rs2241894   10026613383
C___2688509_10rs1789915   10026637155
intron 3 StuI rs1662053   1002665835
C___2688511_10rs1693427   10026682754
rs3762896rs3762896   10026813247
Exon3 Gly78Termrs283413   10026819045
C___8829660_10rs1789920   10026885641
C___2688538_10rs1789924   10027428675
rs11499823rs11499823   10027474950
rs1662037rs1662037   10027881988
C___2688547_10rs980972   100279247Now associated with rs98097262
intron 2 EcoRIrs1789920   10048787948

References:
- Edenberg HJ. "Regulation of the mammalian alcohol dehydrogenase genes". Prog. Nucleic Acid Res. Mol. Biol. 64:295-341. (2000) Online citation.

- Osier MV, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB, and Kidd KK. "Linkage Disequilibrium at the ADH2 and ADH3 Loci and Risk of Alcoholism". Am. J. Hum. Genet. 64:1147-1157. (1999) Online citation.

- Osier MV, Pakstis AJ, Soodyall H, Comas D, Goldman D, Odunsi A, Okonofua F, Parnas J, Schulz LO, Bertranpetit J, Bonne-Tamir B, Lu RB, Kidd JR, Kidd KK. "A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity". Am J Hum Genet 71:84-99. (2002) Online citation.

- Osier MV. "Genetic Variation and Linkage Disequilibrium in the Human Alcohol Dehydrogenase Genes". Dissertation, Yale University (2002)

Top

© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan