ALFRED: allele frequency database

The ALlele FREquency Database
ALFRED is a resource of gene frequency data on human populations
supported by the U. S. National Science Foundation.

ALFRED detailed record information

Locus Information

Name	ALFRED UID	Locus Symbol	Chromosome	Band Position
Fibrinogen, A alpha polypeptide	LO000359R	FGA	4	4q28

Synonyms: Fib2 ;
Sites List: See Sites List
External Resources: Entrez Gene Locus Information OMIM description GenBank sequence GenBank sequence GenBank sequence GenBank sequence GenBank sequence PharmGKB Gene Information Genopedia (HuGE Navigator)
References: See References
Locus Description: The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. FGA consists of six exons and 5 introns, with an untranslated region of approximately 1Kb on the 3' end (Fu et al., 1992). Fibrinogen is cleaved by thrombin to form fibrin, important in the clotting of blood and the products of which regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types including fibroblasts, endothelial and smooth muscle cells (Herrick et al., 1999).

FGA includes one of the 13 CODIS Core STR markers (SI000529Q).
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
Site Name
(Navigates to ALFRED
description) dbSNP rs#
(Navigates to dbSNP
reference page) Chr-Position Status # Populations
typed
rs6825454 rs6825454    155501188 51
rs4308349 rs4308349    155502113 51
rs2070022 rs2070022    155504948 51
rs2070016 rs2070016    155510314 51
rs2070006 rs2070006    155513866 51
FGA tetranucleotide STRP     155728500 165

References:
- Fu Y, Weissbach L, Plant PW, Oddoux C, Cao Y, Liang TJ, Roy SN, Redman CM, Grieninger G. "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits". Biochemistry 31:11968-11972. (1992) Online citation.

- Herrick S, Blanc-Brude O, Gray A, Laurent G. "Fibrinogen". Int J Biochem Cell Biol. 31:741-746. (1999) Online citation.

- Lazaruk K, Wallin J, Holt C, Nguyen T, Walsh PS. "Sequence variation in humans and other primates at six short tandem repeat loci used in forensic identity testing". Forensic Sci Int. 119:1-10. (2001) Online citation.

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© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan