|Name||ALFRED UID||Locus Symbol||Chromosome||Band Position|
|Coagulation factor II (thrombin)||LO000605L||F2||11||p11-q12|
See Sites List
External Resources: Entrez Gene Locus Information OMIM Locus Information Genbank mRNA sequence Genbank Genomic sequence Unigene PharmGKB Gene Information Genopedia (HuGE Navigator)
References: See References
Locus Description: Prothrombin is the precursor of the serine protease thrombin, a key enzyme in the processes of homeostasis and thrombosis.The gene is 21 kb long localized on chromosome 11, position 11p11-q12 (Royle et al. (1987) by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization.The gene is organized in 14 exons separated by 13 introns with the 5¿ and 3¿ untranslated region. The exons range in size from 25 to 315 base pairs, while the introns range from 84 to 9447 base pairs. All the intron splice junctions are consistent with sequences found in other eukaryotic genes, except for the presence of GC rather than GT on the 5' end of intervening sequence (PMID: 2825773). Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
Sites within this locus ordered by their chromosomal position in the 37.3 NCBI build:
| Site Name |
(Navigates to ALFRED
|dbSNP rs# |
(Navigates to dbSNP
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan