|Name||ALFRED UID||Locus Name||Locus Symbol|
|intron 2 TaqI D||SI000139N||Dopamine Receptor D2||DRD2|
|Fst||Avg Het||# Populations Typed|
External Resources: HGVbase Site Definition Record Typing Protocol Record GenBank sequence Record GenBank sequence Record GenBank sequence Record GenBank sequence Record GenBank sequence Record dbSNP ss# Record PharmGKB Variant Information Record
References: See References
Polymorphism Description: A T/C SNP in intron 2 that alters a TaqI restriction site. The SNP is located between the MboI RSP and the (GT)n STRP: 160 bp downstream of the MboI SNP and 1.396 kb upstream of the STRP. With the protocol given, the PCR fragment is 300 bp which remains uncut by TaqI for the D1 allele (site absent) and is cut into fragments of 212 bp and 88 bp for the D2 allele (site present). The MboI site is also within this PCR amplicon.
Ancestral Allele: Site Present
Ancestral Allele Determine by: Sequence on primate DNA
|Allele Name||Allele Symbol||Description|
|Taq Site Absent||T||5'-aaaagagccttgggtt T T GA gactagggaacctggg-3'|
|TaqI Site Present||C||5'-aaaagagccttgggtt T C GA gactagggaacctggg-3'|
- Iyengar S, Seaman M, Deinard AS, Rosenbaum HC, Sirugo G, Castiglione CM, Kidd JR, Kidd KK. "Analyses of cross-species polymerase chain reaction products to infer the ancestral state of human polymorphisms". DNA Seq. 8:317-27. (1998) Online citation.
- Kidd KK, Pakstis AJ, Castiglione CM, Kidd JR, Speed WC, Goldman D, Knowler WC, Lu RB, Bonne-Tamir B. "DRD2 haplotypes containing the TaqI A1 allele: implications for alcoholism research". Alcohol. Clin. Exp. Res. 20:697-705. (1996) Online citation.
- Sawyer SL, Mukherjee N, Pakstis AJ, Feuk L, Kidd JR, Brookes AJ, Kidd KK. "Linkage disequilibrium patterns vary substantially among populations". Eur J Hum Genet 13:677-686. (2005) Online citation.
- Suarez BK, Parsian A, Hampe CL, Todd RD, Reich T, Cloninger CR. "Linkage disequilibria at the D2 dopamine receptor locus (DRD2) in alcoholics and controls". Genomics 19:12-20. (1994) Online citation.
© 2012 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan