The ALlele FREquency Database    ALFRED is a resource of gene frequency data on human populations supported by the Yale Center for Medical Informatics.

Some interesting examples rs17822931    ABC11    G/A SNP (Gly180Arg)   Earwax G/A SNP in the coding region of ABCC11 gene resulting in non-synonymous change Glycine(GGG) -> Arginine(AGG) at aminoacid position 180 of the gene. Allele A is associated with dry earwax type and is common in East Asian populations. References Site:   ALFRED   dbSNP Locus:   ALFRED   OMIM   Entrez Gene View allele frequencies      rs16891982    SLC45A2    C/G SNP (Leu374Phe)   Skin Color C/G SNP in exon 5 of the SLC45A2 gene resulting in the non-synonymous substitution of Leucine (TTG) -> Phenylalanine (TTC) at aminoacid position 374 of the gene. Allele C=Phe, is associated with light skin color and is common only in populations of European ancestry. References Site:   ALFRED   dbSNP Locus:   ALFRED   OMIM   Entrez Gene View allele frequencies      rs3827760    EDAR    C/T SNP (Val370Ala)   Hair thickness C\T SNP in the coding region of EDAR gene resulting in the non-synonymous substitution of Valine (GTT) -> Alanine (GCT) at aminoacid position 370 of the gene. 1540C allele has been reported to be associated with Asian-specific hair thickness. References Site:   ALFRED   dbSNP Locus:   ALFRED   OMIM   Entrez Gene View allele frequencies      3-site haplotype (rs713598,rs1726866,rs10246939)    TAS2R38 / PTC    Taster/nontaster haplotype 3 SNPs (SI000882S  ,  SI001020D  ,  SI000883T) haplotype within the TAS2R38 / PTC gene, all of which result in amino acid changes in the protein. Named in the order of the 3 SNPs, the nontaster haplotype is AVI and the haplotype PAV the taster. The presumed recombinant taster haplotype AAV has been reported to be seen at a frequency 3% among Europeans. References Site:   ALFRED    Locus:   ALFRED   OMIM   Entrez Gene View allele frequencies

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Originally prototyped by Michael Osier with the aid of Kei Cheung
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