ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the Yale Center for Medical Informatics.
00ALFRED detailed record information

Population Information

NameALFRED UIDPrimary LanguageLanguage Family
IrishPO000057MGAELIC, IRISHIndo-European

Synonyms:
Geographic Location1:  56N, 11W; 51N, 6W  

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: Ethnologue: Language Map Record    Ethnologue: Country Description Record    Ethnologue: Language Description Record    
References: See references
Population Description: Ireland appears to have been inhabited as early as 6000 BC. Prehistoric population succession is unclear, however Gaelic-speaking Celtic groups seem to have established themselves on the island by 600 BC. Viking raids began in the 9th century CE, and Norse traders soon settled in coastal areas, founding settlements that grew into Ireland's first cities and towns. The Celts defeated the Norse in 1014, English Normans invaded in 1169. The modern Irish population is roughly 3.5 million. Although English is the dominant language, Irish Gaelic, part of the Gaelic branch of Indo-European, continues to be spoken to some degree by up to 30% of the population.
References:
- North KE, Martin LJ, Crawford MH. "The origins of the Irish Travellers and the genetic structure of Ireland". Annals of Human Biology 27:453-65. (2000)



Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA000057M

Sample Description:The Irish sample was collected by Prof. K. Kendler and collaborators from people born in Ireland predominantly from the northern and central counties. There are 116 cell lines (232 chromosomes) established by Prof. Kendler and Judith R. Kidd

Number of Chromosomes: 232

Relation to Other Samples:

References:
- Kang AM, Palmatier MA, Kidd KK. "Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3)". Biological Psychiatry 46:151-60. (1999) Online citation.

- Palmatier MA, Kang AM, Kidd KK. "Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles". Biol. Psychiatry. 46:557-67. (1999) Online citation.

- Tishkoff SA, Goldman A, Calafell F, Speed WC, Deinard AS, Bonne-Tamir B, Kidd JR, Pakstis AJ, Jenkins T, Kidd KK. "A global haplotype analysis of the myotonic dystrophy locus: implications for the evolution of modern humans and for the origin of myotonic dystrophy mutations". Am. J. Hum. Genet. 62:1389-402. (1998) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA003979C

Sample Description:This sample is the subset of the Kidd Lab Irish sample.This sample was collected by Prof. K. Kendler and collaborators from people born in Ireland predominantly from the northern and central counties.

Number of Chromosomes: 50

Relation to Other Samples: Subset of sample SA000057M

References:
- Publication pending


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Ireland

Sample UID: SA003303J

Sample Description:This sample is from Cork area, Ireland.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 200

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Sheehan D, Bennett T, Cashman K. "Apolipoprotein E gene polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease risk". Ir J Med Sci. 169:50-4. (2000) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA002477U

Sample Description:This sample consists of Irish individuals.

Number of Chromosomes: 62

Relation to Other Samples:

References:
- Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW et.al. "Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes". Am J Hum Genet. 62:1507-15. (1998) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Belfast

Sample UID: SA003243M

Sample Description:This sample consists of individuals from Belfast, Ireland.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 212

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Haddy N, De Bacquer D, Chemaly MM, Maurice M, Ehnholm C, Evans A, Sans S, Do Carmo Martins M, De Backer G, Siest G, Visvikis S. "The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe". Eur J Hum Genet. 10:841-50. (2002) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Ireland

Sample UID: SA002518Q

Sample Description:This sample consists of unrelated individuals from Ireland. This sample was collected as part of anthropological surveys of investigation of non-HIV related medical conditions.

Number of Chromosomes: 88

Relation to Other Samples:

References:
- Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. "Global distribution of the CCR5 gene 32-basepair deletion". Nat Genet 16:100-103. (1997) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Belfast

Sample UID: SA004040I

Sample Description:This sample consists of individuals from Belfast, Northern Ireland. This sample is part of the EUREYE(European Eye Study). The EUREYE Study is multicenter, population-based cross-sectional study from 7 study centers, Bergen, Norway; Tallinn, Estonia; Belfast, Northern Ireland, United Kingdom; Paris-Creteil, France; Verona, Italy; Thessaloniki, Greece; and Alicante, Spain. were chosen primarily to maximize the range of latitude and lifestyle behaviors, including diet.

Number of Chromosomes: 996

Relation to Other Samples:

References:
- Walsh S, Wollstein A, Liu F, Chakravarthy U, Rahu M, Seland JH, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Fletcher AE, Ballantyne KN, Kayser "DNA-based eye colour prediction across Europe with the IrisPlex system". Forensic Sci Int Genet. (Epub, ahead of print) (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA004155P

Sample Description:This sample consists of unrelated Irish individuals. Informed consent was obtained from all donors and ethical approval was obtained from the University College London.

Number of Chromosomes: 94

Relation to Other Samples:

References:
- Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG. "The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans". Am J Hum Genet. 74:1102-10. (2004) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA004378W

Sample Description:This sample is part of Kidd lab sample collection and is subset of sample SA000057M.

Number of Chromosomes: 44

Relation to Other Samples: Subset of SA000057M

References:
- Kenneth K. Kidd et al. "Data unpublished".


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Irish

Sample UID: SA004699C

Sample Description:This sample consists of Irish individuals in Northern Europe. Written informed consent was obtained from all individuals. This sample is part of Caixia Li's group in Institute of Forensic Science, Beijing, China. It was provided by the Kenneth K. Kidd's laboratory to Caixia lab.

Number of Chromosomes: 226

Relation to Other Samples:

References:
- Jiang L, Wei YL, Zhao L, Li N, Liu T, Liu HB, Ren LJ, Li JL, Hao HF, Li Q, Li CX. "Global analysis of population stratification using a smart panel of 27 continental ancestry-informative SNPs". Forensic Sci Int Genet. 35:e10-e12. (2018) Online citation.


1Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

Top


© 2019 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan