ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the Yale Center for Medical Informatics.
00ALFRED detailed record information

Population Information

NameALFRED UIDPrimary LanguageLanguage Family
SardinianPO000411G

Synonyms:
Geographic Location1:  41.25N, 8E; 38.75N, 10E  

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: 
References: See references
Population Description: Being curated
References:


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinia

Sample UID: SA000716O

Sample Description:This sample consists of healthy, unrelated individuals living on the island of Sardinia whose 4 grandparents were native to the Sardinia. The sample was collected at the Civil Hospital of Olbia in Sardinia.

Number of Chromosomes: 452

Relation to Other Samples:

References:
- Corbo RM, Scacchi R, Mureddu L, Mulas G, Alfano G "Apolipoprotein E polymorphism in Italy investigated in native plasma by a simple polyacrylamide gel isoelectric focusing technique. Comparison with frequency data of other European populations". Ann Hum Genet 59:197-209. (1995) Online citation.

- Corbo RM, Scacchi R, Mureddu L, Mulas G, Castrechini S, Rivast P. "Apolipoprotein B, apolipoprotein E, and angiotensin-converting enzyme polymorphisms in 2 Italian populations at different risk for coronary artery disease and comparison of allele frequencies among European populations". Human Biology 71:933-45. (1999) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sulcis

Sample UID: SA001187R

Sample Description:This sample consists of healthy individuals from Sulcis in southern Sardinia. Donors are from both sexes and are not mutually related. They were born and reside on the island, as did their ancestors for at least three generations.

Number of Chromosomes: 74

Relation to Other Samples:

References:
- Latini V, Vacca L, Ristaldi MS, Marongiu MF, Memmi M, Varesi L, Vona G. "Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations". Hum Biol. 75:855-871. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Trexenta

Sample UID: SA001188S

Sample Description:This sample consists of healthy individuals from Trexenta in southern-central Sardinia. Donors are from both sexes and are not mutually related. They were born and reside on the island, as did their ancestors for at least three generations.

Number of Chromosomes: 68

Relation to Other Samples:

References:
- Latini V, Vacca L, Ristaldi MS, Marongiu MF, Memmi M, Varesi L, Vona G. "Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations". Hum Biol. 75:855-871. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Campidano of Oristano

Sample UID: SA001189T

Sample Description:This sample consists of healthy individuals from Campidano of Oristano in central Sardinia. Donors are from both sexes and are not mutually related. They were born and reside on the island, as did their ancestors for at least three generations.

Number of Chromosomes: 72

Relation to Other Samples:

References:
- Latini V, Vacca L, Ristaldi MS, Marongiu MF, Memmi M, Varesi L, Vona G. "Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations". Hum Biol. 75:855-871. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Nuorese

Sample UID: SA001190L

Sample Description:This sample consists of healthy individuals from Nuorese in northern-central Sardinia. Donors are from both sexes and are not mutually related. They were born and reside on the island, as did their ancestors for at least three generations.

Number of Chromosomes: 86

Relation to Other Samples:

References:
- Latini V, Vacca L, Ristaldi MS, Marongiu MF, Memmi M, Varesi L, Vona G. "Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations". Hum Biol. 75:855-871. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Gallura

Sample UID: SA001191M

Sample Description:This sample consists of healthy individuals from the Tempio region of Gallura in northern Sardinia. Donors are from both sexes and are not mutually related. They were born and reside on the island, as did their ancestors for at least three generations.

Number of Chromosomes: 82

Relation to Other Samples:

References:
- Latini V, Vacca L, Ristaldi MS, Marongiu MF, Memmi M, Varesi L, Vona G. "Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations". Hum Biol. 75:855-871. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinian, HGDP-CEPH

Sample UID: SA001505L

Sample Description:This sample from Italy is part of the Human Genome Diversity Cell Line Panel collected by the Human Genome Diversity Project (HGDP) and the Foundation Jean Dausset (CEPH). This sample consists of unrelated individuals and was collected with proper informed consent.

Number of Chromosomes: 56

Relation to Other Samples:

References:
- Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, Feldman MW. "Genetic structure of human populations". Science 298:2381-2385. (2002) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinia

Sample UID: SA001919U

Sample Description:This sample consists of healthy individuals from Sardinia. They were collected by the Istituto di Malattie Infettive of the University of Sassari-Alghero.

Number of Chromosomes: 528

Relation to Other Samples:

References:
- Battiloro E, Andreoni M, Parisi SG, Mura MS, Sotgiu G, Aceti A, Cossu G, Concia E, Verna R, D'Ambrosio E. "Distribution of the CCR5 delta32 allele in Italian HIV type 1-infected and normal individuals.". AIDS Res Hum Retroviruses. 16:181-2. (2000) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinians

Sample UID: SA001871R

Sample Description:This sample consists of unrelated Sardinian individuals from Cagliari, Italy.

Number of Chromosomes: 200

Relation to Other Samples:

References:
- Libert F, Cochaux P, Beckman G, Samson M, Aksenova M, Cao A, Czeizel A, Claustres M, de la Rua C, Ferrari M, Ferrec C, Glover G, Grinde B, Guran S, Kucinskas V, Lavinha J, Mercier B, Ogur G, Peltonen L, Rosatelli C, Schwartz M, Spitsyn V, Timar L, Beckman L, Parmentier M, Vassart G "The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe". Hum Mol Genet. 7:399-406.. (1998) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinian

Sample UID: SA002768X

Sample Description:This sample consists of Sardinians from Italy. This sample was collected by Dr.Marcello Siniscalco.

Number of Chromosomes: 68

Relation to Other Samples:

References:
- Li H & Kidd KK "Low allele frequency of ADH1B*47His in West China and different ADH1B haplotypes in Western Asia from Eastern Asia". Am. J. Med. Genet. 84:92-94. (2009)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinians

Sample UID: SA003155O

Sample Description:This sample consists of Young Sardinian subjects aged 28-50 years. All participants gave informed consent for the study.

Number of Chromosomes: 400

Relation to Other Samples:

References:
- Chillemi R, Angius A, Persico I, Sassu A, Prodi DA, Musumeci S "Methylenetetrahydrofolate Reductase (MTHFR) from Mediterranean to Sub-Saharan Areas". Online Jourmal of Biological Sciences 6:28-34. (2005)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: OldSardinian

Sample UID: SA003156P

Sample Description:This sample consists of Old Sardinian subjects aged 60-90 years. All participants gave informed consent for the study.

Number of Chromosomes: 290

Relation to Other Samples:

References:
- Chillemi R, Angius A, Persico I, Sassu A, Prodi DA, Musumeci S "Methylenetetrahydrofolate Reductase (MTHFR) from Mediterranean to Sub-Saharan Areas". Online Jourmal of Biological Sciences 6:28-34. (2005)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinia

Sample UID: SA003104I

Sample Description:This sample consists of subjects from Sardinia.

Number of Chromosomes: 192

Relation to Other Samples:

References:
- Falchi A, Barsotelli M, Giovannoni L, Varesi L, Vona G "Prevalance of MTHFR gene polymorphisms among Meditarenean populations: a possible genetic selection from Malaria?". 554-556. (2006)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinia

Sample UID: SA003356R

Sample Description:This sample consists of Sardinian individuals.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 1266

Relation to Other Samples:

References:
- Deiana L, Pes GM, Carru C, Errigo A, Pettinato S, Carcassi C, Baggio G, Contu L. "Lack of influence of apolipoprotein E4 on lipoprotein levels in the island population of Sardinia". Eur J Clin Invest. 28:290-4.. (1998) Online citation.

- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Nuoro

Sample UID: SA003596X

Sample Description:This sample consists of Sardinians from Nuoro, Sardinia.

Number of Chromosomes: 188

Relation to Other Samples:

References:
- Via M, Gonzalez-Perez E, Esteban E, Lopez-Alomar A, Vacca L, Vona G, Dugoujon JM, Harich N, Moral P. "Molecular variation in endothelial nitric oxide synthase gene (eNOS) in western Mediterranean populations". Coll Antropol. 27:117-24. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Cabras

Sample UID: SA003597Y

Sample Description:This sample consists of Sardinians from Cabras, Sardinia.

Number of Chromosomes: 190

Relation to Other Samples:

References:
- Via M, Gonzalez-Perez E, Esteban E, Lopez-Alomar A, Vacca L, Vona G, Dugoujon JM, Harich N, Moral P. "Molecular variation in endothelial nitric oxide synthase gene (eNOS) in western Mediterranean populations". Coll Antropol. 27:117-24. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinian

Sample UID: SA004009N

Sample Description:This sample consists of Sardinians from Sardinia.

Number of Chromosomes: 416

Relation to Other Samples:

References:
- Mercier G, Diéterlen F, Lucotte G. "Population distribution of the methionine allele at the PRNP codon 129 polymorphism in Europe and the Middle East". Hum Biol. 80:181-90. (2008) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Sardinian

Sample UID: SA004702N

Sample Description:This sample consists of Sardinian individuals from South Europe. Written informed consent was obtained from all individuals. This sample is part of Caixia Li's group in Institute of Forensic Science, Beijing, China. It was provided by the Kenneth K. Kidd's laboratory to Caixia lab.

Number of Chromosomes: 56

Relation to Other Samples:

References:
- Jiang L, Wei YL, Zhao L, Li N, Liu T, Liu HB, Ren LJ, Li JL, Hao HF, Li Q, Li CX. "Global analysis of population stratification using a smart panel of 27 continental ancestry-informative SNPs". Forensic Sci Int Genet. 35:e10-e12. (2018) Online citation.


1Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

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© 2019 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan