ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the Yale Center for Medical Informatics.
00ALFRED detailed record information

Population Information

NameALFRED UIDPrimary LanguageLanguage Family
BritishPO000412H

Synonyms:
Geographic Location1:  59.5N, 7.5W; 49.75N, 1.75E  

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: 
References: See references
Population Description: Being curated
References:


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Caucasian, British

Sample UID: SA000903M

Sample Description:This sample consists of healthy unrelated British individuals.

Number of Chromosomes: 224

Relation to Other Samples:

References:
- Yoshimoto T, Tamaki K, Katsumata S, Huang XL, Uchihi R, Tanaka M, Uchida H, Yamamoto T, Chen S, Armour JA, Katsumata Y. "Sequence analysis of alleles at a microsatellite locus D14S299 (wg1c5) and population genetic comparisons". Int J Legal Med 113:15-18. (1999) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: British

Sample UID: SA000724N

Sample Description:This sample consists of unrelated individuals. The sample contains 17 men and women aged between 40 and 60 years from Glasgow and 22 males with a mean age of 42 from the Sheffield area.

Number of Chromosomes: 78

Relation to Other Samples:

References:
- Demant T, Houlston RS, Caslake MJ, Series JJ, Shepherd J, Packard CJ, Humphries SE. "Catabolic rate of low density lipoprotein in influenced by variation in the Apolipoprotein B gene". J Clin Invest. 82:797-802. (1988) Online citation.

- Dunning AM, Renges HH, Xu CF, Peacock R, Brasseur R, Laxer G, Tikkanen MJ, Butler R, Saha N, Hamsten A, et al. "Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3' end of the human gene". Am J Hum Genet. 50:208-21. . (1992) Online citation.

- Houlston RS, Turner PR, Revill J, Lewis B, Humphries SE. "The fractional catabolic rate of low density lipoprotein in normal individuals is influenced by variation in the apolipoprotein B gene: a preliminary study". Atherosclerosis 71:81-85. (1988) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: British

Sample UID: SA001714N

Sample Description:This sample consists of paternally unrelated men from the United Kingdom.

Number of Chromosomes: 262

Relation to Other Samples:

References:
- Nadkarni NA, Weale ME, von Schantz M, Thomas MG. "Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system". J Biol Rhythms. 20:490-499. (2005) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Nottinghamshire

Sample UID: SA001952R

Sample Description:This sample consists of healthy unrelated individuals from Nottinghamshire, UK. This sample was collected in collaboration with Trent Regional Centre of the National Blood Service, Sheffield and formed part of ongoing genetic studies in the region.

Number of Chromosomes: 236

Relation to Other Samples:

References:
- Singh PP, Singh M ,Mastana SS "APOE distribution in world populations with new data from India and the UK". Annals of Human Biology 33:279-308. (2006)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: East Midlands

Sample UID: SA001953S

Sample Description:This sample consists of healthy unrelated individuals from East Midlands, UK. This sample was collected in collaboration with Trent Regional Centre of the National Blood Service, Sheffield and formed part of ongoing genetic studies in the region.

Number of Chromosomes: 690

Relation to Other Samples:

References:
- Singh PP, Singh M ,Mastana SS "APOE distribution in world populations with new data from India and the UK". Annals of Human Biology 33:279-308. (2006)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: West Midlands

Sample UID: SA001954T

Sample Description:This sample consists of healthy unrelated individuals from West Midlands, UK. This sample was collected in collaboration with Trent Regional Centre of the National Blood Service, Sheffield and formed part of ongoing genetic studies in the region.

Number of Chromosomes: 316

Relation to Other Samples:

References:
- Singh PP, Singh M ,Mastana SS "APOE distribution in world populations with new data from India and the UK". Annals of Human Biology 33:279-308. (2006)


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: British

Sample UID: SA002476T

Sample Description:This sample consists of British individuals.

Number of Chromosomes: 844

Relation to Other Samples:

References:
- Stephens JC, Reich DE, Goldstein DB, Shin HD, Smith MW et.al. "Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes". Am J Hum Genet. 62:1507-15. (1998) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Britain

Sample UID: SA002514M

Sample Description:This sample consists of unrelated individuals from Britain.

Number of Chromosomes: 566

Relation to Other Samples:

References:
- Martinson JJ, Chapman NH, Rees DC, Liu YT, Clegg JB. "Global distribution of the CCR5 gene 32-basepair deletion". Nat Genet 16:100-103. (1997) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: British(bri)

Sample UID: SA004194S

Sample Description:This sample consists of British.

Number of Chromosomes: 154

Relation to Other Samples:

References:
- Pimenoff VN, Laval G, Comas D, Palo JU, Gut I, Cann H, Excoffier L, Sajantila A. "Similarity in recombination rate and linkage disequilibrium at CYP2C and CYP2D cytochrome P450 gene regions among Europeans indicates signs of selection and no advantage of using tagSNPs in population isolates". Pharmacogenet Genomics. 22:846-857. (2012) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: British from England and Scotland (GBR)

Sample UID: SA004050J

Sample Description:This sample is collected in Cornwall and Kent (England) and Orkney and Argyll & Bute (Scotland), as part of a larger ongoing project (The People of the British Isles - A UK Control population). All of the samples are from unrelated individuals who identified themselves as having all four of their grandparents born in the same rural area.

This sample is part of the 1000 Genomes Collections.

Number of Chromosomes: 182

Relation to Other Samples:

References:
- 1000 genomes phase1 samples data Online citation.

- 1000genomes project samples page Online citation.


1Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

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© 2019 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan