ALFRED: allele frequency database
      The ALlele FREquency Database   
ALFRED is a resource of gene frequency data on human populations
supported by the Yale Center for Medical Informatics.
00ALFRED detailed record information

Population Information

NameALFRED UIDPrimary LanguageLanguage Family
DutchPO000442K

Synonyms:
Geographic Location1:  53.5N, 3.5E; 50.75N, 7.25E  

Sites typed for this population: View List
Population Samples: See Sample Information
External Resources: 
References: See references
Population Description: Being curated
References:


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Dutch

Sample UID: SA000782R

Sample Description:This sample consists of unrelated Dutch Caucasian individuals. The donors were employees and students of the Dutch Forensic Science Laboratory.

Number of Chromosomes: 410

Relation to Other Samples:

References:
- Ovington A, Daselaar P, Sjerps M, Kloosterman A. "A Dutch population study of the STR loci D21S11 and HUMFIBRA". Int J Legal Med 110:14-7. . (1997) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Dutch

Sample UID: SA003635R

Sample Description:This sample consists of 101 childrren(58 boys and 43 girls).

Number of Chromosomes: 202

Relation to Other Samples:

References:
- Rutters F, Nieuwenhuizen AG, Bouwman F, Mariman E, Westerterp-Plantenga MS. "Associations between a Single Nucleotide Polymorphism of the FTO Gene (rs9939609) and Obesity-Related Characteristics over Time during Puberty in a Dutch Children Cohort". J Clin Endocrinol Metab. (Epub, ahead of print) (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Netherlands

Sample UID: SA003290O

Sample Description:This sample consists of Dutch individuals from Leyden(leiden), Netherlands.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 1200

Relation to Other Samples:

References:
- Brenninkmeijer BJ, Stuyt PM, Demacker PN, Stalenhoef AF, van 't Laar A. "Catabolism of chylomicron remnants in normolipidemic subjects in relation to the apoprotein E phenotype". J Lipid Res. 28:361-70.. (1987) Online citation.

- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Amsterdam

Sample UID: SA003291P

Sample Description:This sample consists of Dutch individuals from Amsterdam,Netherlands.

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 1200

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Klasen EC, Smit M, de Kniff P, Gevers Leuven J, Kempen-Voogd R, Havekes L. "Apolipoprotein E phenotype and gene distribution in The Netherlands". Hum Hered. 37:340-4.. (1987) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Doetinchem

Sample UID: SA003292Q

Sample Description:This sample consists of Dutch individuals from Doetinchem,Netherlands

Note: This sample information is not fully curated. For additional information about the sample, consult the publications under "References". The sample was entered as part of data submission by Eisenberg DA.

Number of Chromosomes: 1000

Relation to Other Samples:

References:
- Eisenberg DA, Kuzawa, CW, Hayes MG "Worldwide allele frequencies of the human apolipoprotein E (APOE) gene: climate, local adaptations and evolutionary history". American Journal of Physical Anthropology 143:100-11. (2010) Online citation.

- Klasen EC, Smit M, de Kniff P, Gevers Leuven J, Kempen-Voogd R, Havekes L. "Apolipoprotein E phenotype and gene distribution in The Netherlands". Hum Hered. 37:340-4.. (1987) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Netherlands

Sample UID: SA003697Z

Sample Description:This sample consists of Europeans from Netherlands.

Number of Chromosomes: 400

Relation to Other Samples:

References:
- Acuña-Alonzo V et al. "A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans". Hum Mol Genet 19:2877-85. (2010) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Netherlands, northern region

Sample UID: SA002700J

Sample Description:This sample consists of specimens randomly chosen from newborns whose mothers resided in the northern Netherlands. Specimens consisted of the remainder of blood spots used by the newborn screening programme. This study was conducted under the auspices of the International Clearinghouse for Birth Defect Monitoring Systems (ICBDMS) and was coordinated through its head office, the International Center on Birth Defects. Local review boards approved the study.In all cases personal identifiers were removed before data were provided to ICBD for epidemiological analysis.

Number of Chromosomes: 376

Relation to Other Samples:

References:
- Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, Renlund M, Stoll C, Alembik Y, Dott B, Czeizel AE, Gelman-Kohan Z, Scarano G, Bianca S, Ettore G, Tenconi R, Bellato S, Scala I, Mutchinick OM, López MA, de Walle H, Hofstra R, Joutchenko L, Kavteladze L, Bermejo E, Martínez-Frías ML, Gallagher M, Erickson JD, Vollset SE, Mastroiacovo P, Andria G, Botto LD. "Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide". J Med Genet. 40:619-25.. (2003) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Dutch Europeans

Sample UID: SA004131J

Sample Description:This sample consists of Dutch European subjects aged 45 years or older from the population based Rotterdam Study, Netherlands. This study was approved by the Medical Ethics Committee of the Erasmus University Medical Center.

Number of Chromosomes: 4994

Relation to Other Samples: Subset of SA004045N

References:
- Boehringer S, van der Lijn F, Liu F, Günther M, Sinigerova S, Nowak S, Ludwig KU, Herberz R, Klein S, Hofman A, Uitterlinden AG, Niessen WJ, Breteler MM, van der Lugt A, Würtz RP, Nöthen MM, Horsthemke B, Wieczorek D, Mangold E, Kayser M. "Genetic determination of human facial morphology: links between cleft-lips and normal variation". Eur J Hum Genet. 19:1192-7. (2011) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Dutch Europeans

Sample UID: SA004045N

Sample Description:This sample consists of Dutch Europeans from the Rotterdam study. The Rotterdam Study is a population-based prospective study of subjects aged 55 years or older. The Medical Ethics Committee of the Erasmus Medical Center approved the study protocol, and all participants provided written informed consent. Individuals identified as outliers using and identity-by-state analysis as described previously have been excluded because they most likely represent individuals of non-European ancestry.

Number of Chromosomes: 12840

Relation to Other Samples:

References:
- Liu F, van Duijn K, Vingerling JR, Hofman A, Uitterlinden AG, Janssens AC, Kayser M. "Eye color and the prediction of complex phenotypes from genotypes". Curr Bio 19:R192-3. (2009) Online citation.


Sample Information:

Graph estimated heterozygosities for various sites

Sample Name: Holland

Sample UID: SA004119P

Sample Description:This sample is part of the EPIC study and consists of healthy men and women from Netherlands.

The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study includes participants in 23 centres located in 10 European countries.

Number of Chromosomes: 90

Relation to Other Samples:

References:
- Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K et al. "European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection". Public Health Nutr 5:1113-24. (2002) Online citation.

- Travis RC, Appleby PN, Siddiq A, Allen NE, Kaaks R, Canzian F, Feller S, Tjønneland A, Johnsen NF, Overvad K, Quirós JR, et al. "Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition". Int J Cancer (Epub, ahead of print) (2012) Online citation.


1Geographic Coordinates represent two opposite corners of a rectangle encompassing the area where the population lives.This data is preliminary and changing.

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© 2019 Kenneth K Kidd, Yale University. All rights reserved. The full Copyright Notification is also available.
Originally prototyped by Michael Osier with the aid of Kei Cheung
Upgrades and maintenance since 2002 by Haseena Rajeevan